Clonal cell lines derived from BTI-TN-5B1-4 

Patent No. 7,179,648

Issued: February 20, 2007
Filed: November 14, 2003
PCT Pub. No.: WO20/04/046318
PCT Pub. Date: June 03, 2004

Inventors: Granados; Robert R. (Ithaca, NY), Li; Guoxun (Qingdao, CN)
Assignee: Boyce Thompson Institute for Plant Research, Inc. (Ithaca, NY) 

Improved insect cell lines, two of which are designated H5CL-B and H5CL-F (both of which are derived from the parental cell line BTI-TN-5B1-4, ATCC CRL 10859), possess the properties of increased production of baculovirus particles, increased expression of foreign proteins using a baculovirus expression system, and increased resistance to cell culture stress, relative to the parental cell line.


This application claims an invention which was disclosed in Provisional Application No. 60/426,535, filed Nov. 15, 2002, entitled "IMPROVED CLONAL CELL LINES DERIVED FROM BTI-TN-5B1-4". The benefit under 35 USC .sctn. 119(e) of the United States provisional application is hereby claimed, and the aforementioned application is hereby incorporated herein by reference in its entirety.

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