Baculoviruses with enhanced virion production and a method for the production of baculoviruses

Patent No. 8,961,951

Issued: February 24, 2015
Filed: July 3, 2008
PCT No.: PCT/US2008/069132
371(c)(1),(2),(4) Date: January 06, 2010
PCT Pub. No.: WO2009/014878
PCT Pub. Date: January 29, 2009
Term Extension: 386 days

Inventor: Blissard; Gary (Ithaca, NY), Zhou; Jian (Piscataway, NJ)
Assignee: Boyce Thompson Institute for Plant Research (Ithaca, NY)

The present invention provides a method for restoring budding capability to GP64null baculoviruses including gp64null AcMNPV by expressing therein a portion of the VSV G protein gene or a truncated "stem" portion of the GP64 gene. Other embodiments provide methods to use portions of the G-stem or GP64 protein to target foreign proteins for display on virions.

Reference to Related Applications

This application claims one or more inventions which were disclosed in Provisional Application No. 60/948,214, filed Jul. 6, 2007, entitled "BACULOVIRUSES WITH ENHANCED VIRION PRODUCTION AND A METHOD FOR THE PRODUCTION OF BACULOVIRUSES". The benefit under 35 USC 119(e) of the United States provisional application is hereby claimed, and the aforementioned application is hereby incorporated herein by reference.

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